Cargando…

Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Betulin, or naturally occurring triterpene, possesses promising antiproliferative activity. To further explore this potential, thirty-eight betulin acid ester derivatives modified at the C-28 position were tested for antitumor activities. Four human cancer cell lines, MV4-11 (leukemia), A549 (lung),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pęcak, Paweł, Świtalska, Marta, Chrobak, Elwira, Boryczka, Grzegorz, Bębenek, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820118/ https://www.ncbi.nlm.nih.gov/pubmed/36613643 http://dx.doi.org/10.3390/ijms24010196

Ejemplares similares

Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
por: Bębenek, Ewa, et al.
Publicado: (2019)

New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity
por: Bębenek, Ewa, et al.
Publicado: (2016)

Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity
por: Chrobak, Elwira, et al.
Publicado: (2016)

Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives
por: Bober, Katarzyna, et al.
Publicado: (2019)

Phosphate Derivatives of 3-Carboxyacylbetulin: SynThesis, In Vitro Anti-HIV and Molecular Docking Study
por: Marciniec, Krzysztof, et al.
Publicado: (2020)

Antiproliferative and Cytotoxic Properties of Propynoyl Betulin Derivatives against Human Ovarian Cancer Cells: In Vitro Studies
por: Chodurek, Ewa, et al.
Publicado: (2023)

Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin
por: Chrobak, Elwira, et al.
Publicado: (2021)

New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro
por: Bębenek, Ewa, et al.
Publicado: (2022)

Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone
por: Kadela-Tomanek, Monika, et al.
Publicado: (2021)

Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin
por: Rzepka, Zuzanna, et al.
Publicado: (2022)

Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile
por: Bębenek, Ewa, et al.
Publicado: (2017)

Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro
por: Orchel, Arkadiusz, et al.
Publicado: (2021)

New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study
por: Chrobak, Elwira, et al.
Publicado: (2019)

The Influence of Betulin and Its Derivatives EB5 and ECH147 on the Antioxidant Status of Human Renal Proximal Tubule Epithelial Cells
por: Kruszniewska-Rajs, Celina, et al.
Publicado: (2022)

5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents
por: Kadela-Tomanek, Monika, et al.
Publicado: (2019)

Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits—Synthesis and Antitumor Activity
por: Kadela-Tomanek, Monika, et al.
Publicado: (2017)

Novel triazoles of 3-acetylbetulin and betulone as anticancer agents
por: Bębenek, Ewa, et al.
Publicado: (2018)

Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
por: Boryczka, Stanisław, et al.
Publicado: (2013)

Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
por: Król, Sylwia K., et al.
Publicado: (2021)

Synthesis, Structure and Cytotoxic Activity of Mono- and Dialkoxy Derivatives of 5,8-Quinolinedione
por: Kadela, Monika, et al.
Publicado: (2016)

Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis
por: Marciniec, Krzysztof, et al.
Publicado: (2020)

Lup-20(29)-en-28-ol-3-one (betulone)
por: Boryczka, Stanisław, et al.
Publicado: (2013)

Lipophilicity and ADMET Analysis of Quinoline-1,4-quinone Hybrids
por: Kadela-Tomanek, Monika, et al.
Publicado: (2022)

Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT(1A), 5-HT(7), and D(2) receptor ligands
por: Marciniec, Krzysztof, et al.
Publicado: (2018)

Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1)
por: Kadela-Tomanek, Monika, et al.
Publicado: (2022)

Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
por: Boryczka, Stanisław, et al.
Publicado: (2010)

Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
por: Marciniec, Krzysztof, et al.
Publicado: (2023)

Caspase cascade pathways of apoptosis in oral pemphigus: An immunohistochemical study
por: Sanath, Aparna K, et al.
Publicado: (2018)

Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
por: Drąg-Zalesińska, Małgorzata, et al.
Publicado: (2017)

Comprehensive Review on Betulin as a Potent Anticancer Agent
por: Król, Sylwia Katarzyna, et al.
Publicado: (2015)

The Calpain, Caspase 12, Caspase 3 Cascade Leading to Apoptosis Is Altered in F508del-CFTR Expressing Cells
por: Kerbiriou, Mathieu, et al.
Publicado: (2009)

Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma
por: Eichenmüller, M, et al.
Publicado: (2010)

Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters
por: Li, Zhengning, et al.
Publicado: (2015)

Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines in vitro and in vivo
por: Wang, Wei, et al.
Publicado: (2018)

Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer
por: Guo, Yangyang, et al.
Publicado: (2020)

Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis
por: Lee, Dahae, et al.
Publicado: (2019)

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
por: Hirata, Hirokazu, et al.
Publicado: (1998)

Protease-responsive mass barcoded nanotranslators for simultaneously quantifying the intracellular activity of cascaded caspases in apoptosis pathways
por: Xu, Hongmei, et al.
Publicado: (2020)

High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells?
por: Małaczewska, Joanna, et al.
Publicado: (2021)

Correction to: Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer
por: Guo, Yangyang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gq9mrdedr4lq3qud6pc8v8tg76