Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

DNA polymerase theta (Polθ)-mediated end joining (TMEJ) is, along with homologous recombination (HR) and non-homologous end-joining (NHEJ), one of the most important mechanisms repairing potentially lethal DNA double-strand breaks (DSBs). Polθ is becoming a new target in cancer research because it d...

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Detalles Bibliográficos
Autores principales: Barszczewska-Pietraszek, Gabriela, Drzewiecka, Małgorzata, Czarny, Piotr, Skorski, Tomasz, Śliwiński, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820168/
https://www.ncbi.nlm.nih.gov/pubmed/36613762
http://dx.doi.org/10.3390/ijms24010319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820168/
https://www.ncbi.nlm.nih.gov/pubmed/36613762
http://dx.doi.org/10.3390/ijms24010319

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