Cargando…

Simultaneous Antagonism at H3R/D2R/D3R Reduces Autism-like Self-Grooming and Aggressive Behaviors by Mitigating MAPK Activation in Mice

Dysregulation in brain neurotransmitters underlies several neuropsychiatric disorders, e.g., autism spectrum disorder (ASD). Also, abnormalities in the extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway pave the way for neuroinflammation, neurodegeneration, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eissa, Nermin, Awad, Mohamed Al, Thomas, Shilu Deepa, Venkatachalam, Karthikkumar, Jayaprakash, Petrilla, Zhong, Sicheng, Stark, Holger, Sadek, Bassem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820264/ https://www.ncbi.nlm.nih.gov/pubmed/36613969 http://dx.doi.org/10.3390/ijms24010526

Ejemplares similares

Experimental Studies Indicate That ST-2223, the Antagonist of Histamine H3 and Dopamine D2/D3 Receptors, Restores Social Deficits and Neurotransmission Dysregulation in Mouse Model of Autism
por: Eissa, Nermin, et al.
Publicado: (2022)

The Multi-Targeting Ligand ST-2223 with Histamine H(3) Receptor and Dopamine D(2)/D(3) Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice
por: Eissa, Nermin, et al.
Publicado: (2021)

Simultaneous Blockade of Histamine H(3) Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism
por: Eissa, Nermin, et al.
Publicado: (2020)

The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
por: Eissa, Nermin, et al.
Publicado: (2018)

The Novel Pimavanserin Derivative ST-2300 with Histamine H(3) Receptor Affinity Shows Reduced 5-HT(2A) Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice
por: Venkatachalam, Karthikkumar, et al.
Publicado: (2022)

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice
por: Abdalla, Sabna, et al.
Publicado: (2023)

The Dual-Active Histamine H(3) Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice
por: Eissa, Nermin, et al.
Publicado: (2020)

The D1 family dopamine receptor, DopR, potentiates hind leg grooming behavior in Drosophila
por: Pitmon, E., et al.
Publicado: (2016)

Impact of Alternative Inputs and Jet Grooming on Large-R Jet Performance
por: The ATLAS collaboration
Publicado: (2019)

Canagliflozin Ameliorates Oxidative Stress and Autistic-like Features in Valproic-Acid-Induced Autism in Rats: Comparison with Aripiprazole Action
por: Nakhal, Mohammed Moutaz, et al.
Publicado: (2023)

Impact of Alternative Inputs and Grooming Methods on Large-R Jet Reconstruction in ATLAS
por: The ATLAS collaboration
Publicado: (2017)

Alternative Inputs and Grooming on Large-R Jets in Run 2 of the ATLAS Detector
por: Nelson, Michael Edward, et al.
Publicado: (2018)

Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder
por: Alhusaini, Mera, et al.
Publicado: (2022)

Synthesis, Molecular Properties Estimations, and Dual Dopamine D(2) and D(3) Receptor Activities of Benzothiazole-Based Ligands
por: Schübler, Moritz, et al.
Publicado: (2017)

Curcumin Potentiates α7 Nicotinic Acetylcholine Receptors and Alleviates Autistic-Like Social Deficits and Brain Oxidative Stress Status in Mice
por: Jayaprakash, Petrilla, et al.
Publicado: (2021)

Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?
por: Eissa, Nermin, et al.
Publicado: (2020)

Dopamine Receptor D(1)R and D(3)R and GRK4 Interaction in Hypertension
por: Zeng, Chunyu, et al.
Publicado: (2023)

Combined Analysis of R(D), R(D*)
por: Robinson, Dean
Publicado: (2017)

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats
por: Eissa, Nermin, et al.
Publicado: (2018)

$R$-dependence of inclusive jet suppression and groomed jet splittings in heavy-ion collisions with ALICE
por: Bossi, Hannah
Publicado: (2023)

R&D Agreement 3DprintScint
por: Hertzog, Samuel Joseph
Publicado: (2019)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

$R (D)$ and $R(D^*)$ measurements at LHCb-muonic channels
por: Hamilton, Brian
Publicado: (2017)

$R(D^∗)$ and R(D) with τ − → μ−ντ νμ
por: Ciezarek, Gregory Max
Publicado: (2022)

High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice
por: Boateng, Comfort A., et al.
Publicado: (2015)

Summary of WG3: Accelerator Studies and R&D
por: Keil, Eberhard
Publicado: (2001)

GroomRL: jet grooming through reinforcement learning
por: Dreyer, Frederic Alexandre
Publicado: (2019)

Repurposing Dimethyl Fumarate for Cardiovascular Diseases: Pharmacological Effects, Molecular Mechanisms, and Therapeutic Promise
por: Thomas, Shilu Deepa, et al.
Publicado: (2022)

mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder
por: Thomas, Shilu Deepa, et al.
Publicado: (2023)

Experimental mini-review on $R(D)$ and $R(D^*)$ measurements at LHCb
por: Bozzi, Concezio
Publicado: (2017)

Experimental mini-review on $R(D)$ and $R(D^*)$ measurements at LHCb
por: Bozzi, Concezio
Publicado: (2016)

R&D Management Conference: Using IT Effectively in R&D Management
Publicado: (1996)

First joint measurement of $R(D^*)$ and $R(D^0)$ at LHCb
por: Ciezarek, Gregory Max
Publicado: (2022)

Studies of the impact and mitigation of pile-up on large-$R$ and groomed jets in ATLAS at $\sqrt{s}=7$ TeV
por: The ATLAS collaboration
Publicado: (2012)

Interlock system for R-B, R-Q, R-M and T-D
por: Giesch, M, et al.
Publicado: (1970)

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
por: Bastaki, Salim M, et al.
Publicado: (2018)

MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways
por: Tran, Anh T., et al.
Publicado: (2019)

R3D-BLAST: a search tool for similar RNA 3D substructures
por: Liu, Yun-Chen, et al.
Publicado: (2011)

Enhanced MAPK signaling is essential for CSF3R induced leukemia
por: Rohrabaugh, Sara, et al.
Publicado: (2016)

Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes
por: Watkins, Norman E., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bo31sh67ogtp2g1pugaagleh3v