HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters

The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible factor (HIF-1α) transcriptional pathway is activated, perhaps due to a lack of oxygen or an accumulation of mitochondrial reactive oxygen species...

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Detalles Bibliográficos
Autores principales: Jana, Sirsendu, Heaven, Michael R., Stauft, Charles B., Wang, Tony T., Williams, Matthew C., D’Agnillo, Felice, Alayash, Abdu I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820273/
https://www.ncbi.nlm.nih.gov/pubmed/36614003
http://dx.doi.org/10.3390/ijms24010558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820273/
https://www.ncbi.nlm.nih.gov/pubmed/36614003
http://dx.doi.org/10.3390/ijms24010558

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