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HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters

The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible factor (HIF-1α) transcriptional pathway is activated, perhaps due to a lack of oxygen or an accumulation of mitochondrial reactive oxygen species...

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Detalles Bibliográficos
Autores principales:	Jana, Sirsendu, Heaven, Michael R., Stauft, Charles B., Wang, Tony T., Williams, Matthew C., D’Agnillo, Felice, Alayash, Abdu I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820273/ https://www.ncbi.nlm.nih.gov/pubmed/36614003 http://dx.doi.org/10.3390/ijms24010558

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