(α)N-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers

The opioid peptide β-endorphin coexists in the pituitary and brain in its (α)N-acetylated form, which does not bind to opioid receptors. We now report that these neuropeptides exhibited opposite effects in in vivo paradigms, in which ligands of the sigma type 1 receptor (σ1R) displayed positive effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Garzón-Niño, Javier, Cortés-Montero, Elsa, Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820303/
https://www.ncbi.nlm.nih.gov/pubmed/36614024
http://dx.doi.org/10.3390/ijms24010582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820303/
https://www.ncbi.nlm.nih.gov/pubmed/36614024
http://dx.doi.org/10.3390/ijms24010582

Ejemplares similares