An Inverse Agonist GSK5182 Increases Protein Stability of the Orphan Nuclear Receptor ERRγ via Inhibition of Ubiquitination

The orphan nuclear receptor, estrogen-related receptor γ (ERRγ) is a constitutively active transcription factor involved in mitochondrial metabolism and energy homeostasis. GSK5182, a specific inverse agonist of ERRγ that inhibits transcriptional activity, induces a conformational change in ERRγ, re...

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Detalles Bibliográficos
Autores principales: Na, Soon-Young, Kim, Ki-Sun, Jung, Yoon Seok, Kim, Don-Kyu, Kim, Jina, Cho, Sung Jin, Lee, In-Kyu, Chung, Jongkyeong, Kim, Jeong-Sun, Choi, Hueng-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820335/
https://www.ncbi.nlm.nih.gov/pubmed/36613556
http://dx.doi.org/10.3390/ijms24010096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820335/
https://www.ncbi.nlm.nih.gov/pubmed/36613556
http://dx.doi.org/10.3390/ijms24010096

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