Molecular Dynamics Investigation of MFS Efflux Pump MdfA Reveals an Intermediate State between Its Inward and Outward Conformations

Multidrug resistance poses a major challenge to antibiotic therapy. A principal cause of antibiotic resistance is through active export by efflux pumps embedded in the bacterial membrane. Major facilitator superfamily (MFS) efflux pumps constitute a major group of transporters, which are often relat...

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Detalles Bibliográficos
Autores principales: Li, Ying, Ge, Xizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820426/
https://www.ncbi.nlm.nih.gov/pubmed/36613823
http://dx.doi.org/10.3390/ijms24010356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820426/
https://www.ncbi.nlm.nih.gov/pubmed/36613823
http://dx.doi.org/10.3390/ijms24010356

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