Asymmetric Synthesis of Trifluoroethyl-Based, Chiral 3-Benzyloxy-1- and -2-Phenyl-quinazolinones of Biomedicinal Interest by Radical Type Cross-Coupling to Olefins

Several 2-substituted (H, Ph, and S-Me) and 1-substituted (H, Ph, and Bn), 3-hydroxy-1,3-quinazolin(di)ones were utilized for the first time as radical trapping agents in asymmetric 1,2-oxytrifluoromethylation of styrenes catalyzed by chiral vanadyl methoxide complexes bearing 3,5-disubstituted-N-sa...

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Detalles Bibliográficos
Autores principales: Chen, Chien-Tien, Chang, Yu-Chang, Tseng, Pin-Xuan, Lein, Chien-I, Hung, Shiang-Fu, Wu, Hsyueh-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820497/
https://www.ncbi.nlm.nih.gov/pubmed/36613960
http://dx.doi.org/10.3390/ijms24010513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820497/
https://www.ncbi.nlm.nih.gov/pubmed/36613960
http://dx.doi.org/10.3390/ijms24010513

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