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The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance

Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary me...

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Detalles Bibliográficos
Autores principales: Carloni, Vinicio, Morganti, Elisa, Galli, Andrea, Mazzocca, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820635/
https://www.ncbi.nlm.nih.gov/pubmed/36613695
http://dx.doi.org/10.3390/ijms24010245
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author Carloni, Vinicio
Morganti, Elisa
Galli, Andrea
Mazzocca, Antonio
author_facet Carloni, Vinicio
Morganti, Elisa
Galli, Andrea
Mazzocca, Antonio
author_sort Carloni, Vinicio
collection PubMed
description Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors.
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spelling pubmed-98206352023-01-07 The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance Carloni, Vinicio Morganti, Elisa Galli, Andrea Mazzocca, Antonio Int J Mol Sci Review Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors. MDPI 2022-12-23 /pmc/articles/PMC9820635/ /pubmed/36613695 http://dx.doi.org/10.3390/ijms24010245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carloni, Vinicio
Morganti, Elisa
Galli, Andrea
Mazzocca, Antonio
The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title_full The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title_fullStr The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title_full_unstemmed The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title_short The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
title_sort adaptability of chromosomal instability in cancer therapy and resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820635/
https://www.ncbi.nlm.nih.gov/pubmed/36613695
http://dx.doi.org/10.3390/ijms24010245
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