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The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance
Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary me...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820635/ https://www.ncbi.nlm.nih.gov/pubmed/36613695 http://dx.doi.org/10.3390/ijms24010245 |
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author | Carloni, Vinicio Morganti, Elisa Galli, Andrea Mazzocca, Antonio |
author_facet | Carloni, Vinicio Morganti, Elisa Galli, Andrea Mazzocca, Antonio |
author_sort | Carloni, Vinicio |
collection | PubMed |
description | Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors. |
format | Online Article Text |
id | pubmed-9820635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98206352023-01-07 The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance Carloni, Vinicio Morganti, Elisa Galli, Andrea Mazzocca, Antonio Int J Mol Sci Review Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors. MDPI 2022-12-23 /pmc/articles/PMC9820635/ /pubmed/36613695 http://dx.doi.org/10.3390/ijms24010245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carloni, Vinicio Morganti, Elisa Galli, Andrea Mazzocca, Antonio The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title_full | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title_fullStr | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title_full_unstemmed | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title_short | The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance |
title_sort | adaptability of chromosomal instability in cancer therapy and resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820635/ https://www.ncbi.nlm.nih.gov/pubmed/36613695 http://dx.doi.org/10.3390/ijms24010245 |
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