H(2)O(2) Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling

In diabetes, the enzyme arginase is upregulated, which may compete with endothelial nitric oxide (NO) synthase (eNOS) for their common substrate L-arginine and compromise NO-mediated vasodilation. However, this eNOS uncoupling can lead to superoxide production and possibly vasodilator hydrogen perox...

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Detalles Bibliográficos
Autores principales: Thengchaisri, Naris, Kuo, Lih, Hein, Travis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820654/
https://www.ncbi.nlm.nih.gov/pubmed/36613929
http://dx.doi.org/10.3390/ijms24010489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820654/
https://www.ncbi.nlm.nih.gov/pubmed/36613929
http://dx.doi.org/10.3390/ijms24010489

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