Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations

Dexmedetomidine is a selective α(2)-adrenoceptor agonist and appears to disinhibit endogenous sleep-promoting pathways, as well as to attenuate noradrenergic excitation. Recent evidence suggests that dexmedetomidine might also directly inhibit hyperpolarization-activated cyclic-nucleotide gated (HCN...

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Detalles Bibliográficos
Autores principales: Schwerin, Stefan, Westphal, Catharina, Klug, Claudia, Schneider, Gerhard, Kreuzer, Matthias, Haseneder, Rainer, Kratzer, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820684/
https://www.ncbi.nlm.nih.gov/pubmed/36613961
http://dx.doi.org/10.3390/ijms24010519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820684/
https://www.ncbi.nlm.nih.gov/pubmed/36613961
http://dx.doi.org/10.3390/ijms24010519

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