Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study

The Kirsten rat sarcoma viral G12C (KRAS(G12C)) protein is one of the most common mutations in non-small-cell lung cancer (NSCLC). KRAS(G12C) inhibitors are promising for NSCLC treatment, but their weaker activity in resistant tumors is their drawback. This study aims to identify new KRAS(G12C) inhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Srisongkram, Tarapong, Weerapreeyakul, Natthida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821013/
https://www.ncbi.nlm.nih.gov/pubmed/36614109
http://dx.doi.org/10.3390/ijms24010669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821013/
https://www.ncbi.nlm.nih.gov/pubmed/36614109
http://dx.doi.org/10.3390/ijms24010669

Ejemplares similares