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Drug Repurposing against KRAS Mutant G12C: A Machine Learning, Molecular Docking, and Molecular Dynamics Study

The Kirsten rat sarcoma viral G12C (KRAS(G12C)) protein is one of the most common mutations in non-small-cell lung cancer (NSCLC). KRAS(G12C) inhibitors are promising for NSCLC treatment, but their weaker activity in resistant tumors is their drawback. This study aims to identify new KRAS(G12C) inhi...

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Detalles Bibliográficos
Autores principales:	Srisongkram, Tarapong, Weerapreeyakul, Natthida
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821013/ https://www.ncbi.nlm.nih.gov/pubmed/36614109 http://dx.doi.org/10.3390/ijms24010669

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