Cargando…

Association of Alpha-1 Antitrypsin Pi*Z Allele Frequency and Progressive Liver Fibrosis in Two Chronic Hepatitis C Cohorts

(1) Background: The inherited alpha-1 antitrypsin (A1AT) deficiency variant ‘Pi*Z’ emerged as a genetic modifier of chronic liver disease. Controversial data exist on the relevance of heterozygous Pi*Z carriage (‘Pi*MZ’ genotype) as an additional risk factor in patients with chronic viral hepatitis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mücke, Victoria Therese, Fischer, Janett, Mücke, Marcus Maximilian, Teumer, Alexander, Koch, Alexander, Vermehren, Johannes, Fromme, Malin, Zeuzem, Stefan, Trautwein, Christian, Sarrazin, Christoph, Berg, Thomas, Zhou, Biaohuan, Hamesch, Karim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821389/ https://www.ncbi.nlm.nih.gov/pubmed/36615054 http://dx.doi.org/10.3390/jcm12010253

Ejemplares similares

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice
por: Guldiken, Nurdan, et al.
Publicado: (2019)

Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study
por: Mücke, Marcus M, et al.
Publicado: (2018)

First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report
por: Mücke, Victoria Therese, et al.
Publicado: (2021)

Prevalence of PI*Z and PI*S alleles of alpha-1-antitrypsin deficiency in Finland
por: Häggblom, Jan, et al.
Publicado: (2015)

Heterozygosity of the Alpha 1‐Antitrypsin Pi*Z Allele and Risk of Liver Disease
por: Hakim, Aaron, et al.
Publicado: (2021)

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients
por: Sark, Annelot D., et al.
Publicado: (2022)

Heterozygosity for the alpha‐1‐antitrypsin Z allele in cirrhosis is associated with more advanced disease
por: Schaefer, Benedikt, et al.
Publicado: (2018)

Serum sphingolipid levels associate with upcoming virologic events and HBV genotype D in a cohort of patients with HBeAg-negative HBV infection
por: Mücke, Victoria Therese, et al.
Publicado: (2018)

Quantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency alleles
por: Donato, L. J., et al.
Publicado: (2015)

Point Shear‐Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver‐Related Events in Patients With Chronic Viral Hepatitis
por: Hernandez Sampere, Lisa, et al.
Publicado: (2020)

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs
por: Tumpara, Srinu, et al.
Publicado: (2021)

Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy
por: Mücke, Marcus M., et al.
Publicado: (2019)

Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization
por: Berthelier, Valerie, et al.
Publicado: (2015)

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin
por: Laffranchi, Mattia, et al.
Publicado: (2020)

High Serum Level of IL-17 in Patients with Chronic Obstructive Pulmonary Disease and the Alpha-1 Antitrypsin PiZ Allele
por: Pervakova, Margarita Y., et al.
Publicado: (2020)

Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant
por: JANG, BO-YUN, et al.
Publicado: (2015)

Prevalence of alpha-1 antitrypsin deficiency and allele frequency in patients with COPD in Brazil
por: Russo, Rodrigo, et al.
Publicado: (2016)

Alpha 1 Antitrypsin Deficiency, Two Cases of Heterozygous S and Clayton Null Alleles
por: Rosenbaum, Eric M., et al.
Publicado: (2017)

Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease
por: Balcar, Lorenz, et al.
Publicado: (2022)

Comparison of non-invasive assessment of liver fibrosis in patients with alpha1-antitrypsin deficiency using magnetic resonance elastography (MRE), acoustic radiation force impulse (ARFI) Quantification, and 2D-shear wave elastography (2D-SWE)
por: Reiter, Rolf, et al.
Publicado: (2018)

Risk factors for symptom onset in PI*Z alpha-1 antitrypsin deficiency
por: Mayer, Annyce S, et al.
Publicado: (2006)

Normal Alpha-1-Antitrypsin Variants Display in Serum Allele-Specific Protein Levels
por: Jager, Shelley, et al.
Publicado: (2023)

Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation
por: Mücke, Victoria Therese, et al.
Publicado: (2018)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy
por: Kosinski, Przemyslaw, et al.
Publicado: (2021)

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
por: Pini, Laura, et al.
Publicado: (2014)

Erdj3 Has an Essential Role for Z Variant Alpha‐1‐Antitrypsin Degradation
por: Khodayari, Nazli, et al.
Publicado: (2017)

Hypopituitarism in Wilson’s disease resolved after copper-chelating therapy
por: Dauth, Nina, et al.
Publicado: (2021)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

The unfolded protein response to PI*Z alpha‐1 antitrypsin in human hepatocellular and murine models
por: Lu, Yuanqing, et al.
Publicado: (2022)

Distribution of alpha1 antitrypsin rare alleles in six countries: Results from the Progenika diagnostic network
por: Lopez-Campos, José Luis, et al.
Publicado: (2023)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
por: Fähndrich, Sebastian, et al.
Publicado: (2017)

Impact of colonization with multidrug-resistant organisms on antibiotic prophylaxis in patients with cirrhosis and variceal bleeding
por: Mücke, Victoria T., et al.
Publicado: (2022)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update
por: Blanco, Ignacio, et al.
Publicado: (2017)

Secondary sclerosing cholangitis following COVID-19 disease: a multicenter retrospective study
por: Hunyady, Peter, et al.
Publicado: (2022)

International patenting in ophthalmology: An analysis of its structure and relevance for the development of drugs and diagnostics
por: Mucke, Hermann AM, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jr18r2bk8qk0spdlevbb05epj8