Mathematical models for biomarker calculation of drug-induced liver injury in humans and experimental models based on gadoxetate enhanced magnetic resonance imaging

BACKGROUND: Drug induced liver injury (DILI) is a major concern when developing new drugs. A promising biomarker for DILI is the hepatic uptake rate of the contrast agent gadoxetate. This rate can be estimated using a novel approach combining magnetic resonance imaging and mathematical modeling. How...

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Detalles Bibliográficos
Autores principales: Karlsson, Markus, Simonsson, Christian, Dahlström, Nils, Cedersund, Gunnar, Lundberg, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821424/
https://www.ncbi.nlm.nih.gov/pubmed/36608050
http://dx.doi.org/10.1371/journal.pone.0279168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821424/
https://www.ncbi.nlm.nih.gov/pubmed/36608050
http://dx.doi.org/10.1371/journal.pone.0279168

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