Cargando…
Blockers of Skeletal Muscle Na(v)1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back
The voltage-gated sodium channels represent an important target for drug discovery since a large number of physiological processes are regulated by these channels. In several excitability disorders, including epilepsy, cardiac arrhythmias, chronic pain, and non-dystrophic myotonia, blockers of volta...
Autores principales: | De Bellis, Michela, Boccanegra, Brigida, Cerchiara, Alessandro Giovanni, Imbrici, Paola, De Luca, Annamaria |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821513/ https://www.ncbi.nlm.nih.gov/pubmed/36614292 http://dx.doi.org/10.3390/ijms24010857 |
Ejemplares similares
-
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide
por: De Luca, Annamaria, et al.
Publicado: (2012) -
Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential
por: De Bellis, Michela, et al.
Publicado: (2018) -
Pharmacological Therapies of Spinal Muscular Atrophy: A Narrative Review of Preclinical, Clinical–Experimental, and Real-World Evidence
por: Crisafulli, Salvatore, et al.
Publicado: (2023) -
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model
por: Boccanegra, Brigida, et al.
Publicado: (2023) -
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks
por: Boccanegra, Brigida, et al.
Publicado: (2020)