α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death

KRAS is the most frequently mutated oncogene associated with the genesis and progress of pancreatic, lung and colorectal (CRC) tumors. KRAS has always been considered as a therapeutic target in cancer but until now only two compounds that inhibit one specific KRAS mutation have been approved for cli...

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Detalles Bibliográficos
Autores principales: Abuasaker, Baraa, Garrido, Eduardo, Vilaplana, Marta, Gómez-Zepeda, Jesús Daniel, Brun, Sonia, Garcia-Cajide, Marta, Mauvezin, Caroline, Jaumot, Montserrat, Pujol, Maria Dolors, Rubio-Martínez, Jaime, Agell, Neus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821572/
https://www.ncbi.nlm.nih.gov/pubmed/36614192
http://dx.doi.org/10.3390/ijms24010748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821572/
https://www.ncbi.nlm.nih.gov/pubmed/36614192
http://dx.doi.org/10.3390/ijms24010748

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