Dexmedetomidine Attenuates Methotrexate-Induced Neurotoxicity and Memory Deficits in Rats through Improving Hippocampal Neurogenesis: The Role of miR-15a/ROCK-1/ERK1/2/CREB/BDNF Pathway Modulation

Methotrexate (MTX) is a widely used neurotoxic drug with broad antineoplastic and immunosuppressant spectra. However, the exact molecular mechanisms by which MTX inhibits hippocampal neurogenesis are yet unclear. Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, has recently shown neuroprote...

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Detalles Bibliográficos
Autores principales: Taha, Mohamed, Eldemerdash, Omar Mohsen, Elshaffei, Ismail Mohamed, Yousef, Einas Mohamed, Senousy, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821704/
https://www.ncbi.nlm.nih.gov/pubmed/36614208
http://dx.doi.org/10.3390/ijms24010766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821704/
https://www.ncbi.nlm.nih.gov/pubmed/36614208
http://dx.doi.org/10.3390/ijms24010766

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