The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers

The human homologue of mouse Ly-1 antibody reactive clone protein (LYAR) is a putative novel regulator of γ-globin gene transcription. The LYAR DNA-binding motif (5′-GGTTAT-3′) is located within the 5′-UTR of the Aγ-globin gene. The LYAR rs368698783 (G>A) polymorphism is present in β-thalassemia...

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Detalles Bibliográficos
Autores principales: Zuccato, Cristina, Cosenza, Lucia Carmela, Zurlo, Matteo, Breveglieri, Giulia, Bianchi, Nicoletta, Lampronti, Ilaria, Gasparello, Jessica, Scapoli, Chiara, Borgatti, Monica, Finotti, Alessia, Gambari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821710/
https://www.ncbi.nlm.nih.gov/pubmed/36614221
http://dx.doi.org/10.3390/ijms24010776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821710/
https://www.ncbi.nlm.nih.gov/pubmed/36614221
http://dx.doi.org/10.3390/ijms24010776

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