Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866

NAMPT is an attractive target in cancer therapy and numerous NAMPT inhibitors have been developed. However, the clinical activities of NAMPT inhibitors have displayed disappointing results in clinical trials for their dose-limiting toxicities. In this study, reactive oxygen species (ROS)-responsive...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Zili, Wang, Huihui, Liu, Haixia, Chen, Hongli, Jiang, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821821/
https://www.ncbi.nlm.nih.gov/pubmed/36615364
http://dx.doi.org/10.3390/molecules28010169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821821/
https://www.ncbi.nlm.nih.gov/pubmed/36615364
http://dx.doi.org/10.3390/molecules28010169

Ejemplares similares