Cargando…

Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866

NAMPT is an attractive target in cancer therapy and numerous NAMPT inhibitors have been developed. However, the clinical activities of NAMPT inhibitors have displayed disappointing results in clinical trials for their dose-limiting toxicities. In this study, reactive oxygen species (ROS)-responsive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Zili, Wang, Huihui, Liu, Haixia, Chen, Hongli, Jiang, Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821821/ https://www.ncbi.nlm.nih.gov/pubmed/36615364 http://dx.doi.org/10.3390/molecules28010169

Ejemplares similares

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
por: Barraud, Marine, et al.
Publicado: (2016)

The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells
por: Parisotto, Maxime, et al.
Publicado: (2022)

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
por: Esposito, Emanuela, et al.
Publicado: (2012)

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth
por: Pant, Kishor, et al.
Publicado: (2023)

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
por: Thakur, Basant Kumar, et al.
Publicado: (2013)

Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment
por: Ogino, Yoko, et al.
Publicado: (2018)

IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells
por: Maleki Vareki, Saman, et al.
Publicado: (2015)

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib
por: Bielec, Bjoern, et al.
Publicado: (2020)

FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells
por: Zhang, Bin, et al.
Publicado: (2018)

MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
por: Huang, Peixin, et al.
Publicado: (2017)

Neuroprotective effects of FK866 against traumatic brain injury: Involvement of p38/ERK pathway
por: Tan, Zhongju, et al.
Publicado: (2020)

FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence
por: Ok, Chang Youp, et al.
Publicado: (2021)

A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1
por: Deng, Yuxuan, et al.
Publicado: (2022)

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent
por: Cloux, Anne-Julie, et al.
Publicado: (2019)

FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
por: Guo, Enshuang, et al.
Publicado: (2017)

Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
por: Park, Minjae, et al.
Publicado: (2022)

Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy
por: Guo, Zhaopei, et al.
Publicado: (2022)

COLLABORATION AGREEMENT K 866
por: THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH, CERN, et al.
Publicado: (2002)

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads
por: Chirumamilla, Chandra S., et al.
Publicado: (2017)

Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment
por: Oddone, Natalia, et al.
Publicado: (2020)

Review of various NAMPT inhibitors for the treatment of cancer
por: Wei, Yichen, et al.
Publicado: (2022)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

Supramolecular Caffeic Acid and Bortezomib Nanomedicine: Prodrug Inducing Reactive Oxygen Species and Inhibiting Cancer Cell Survival
por: Aguilar, Ludwig Erik, et al.
Publicado: (2020)

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors
por: Wang, Weiru, et al.
Publicado: (2014)

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT
por: Wang, Xia, et al.
Publicado: (2015)

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
por: Fons, Nathan R., et al.
Publicado: (2019)

The Role of Reactive Oxygen Species in Arsenic Toxicity
por: Hu, Yuxin, et al.
Publicado: (2020)

New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology
por: Roulston, Anne, et al.
Publicado: (2015)

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy
por: Galli, Ubaldina, et al.
Publicado: (2020)

HGG-33. EXPLOITING METABOLIC DEFECTS WITH NAMPT INHIBITORS IN DIPG
por: Muraleedharan, Ranjithmenon, et al.
Publicado: (2021)

Role of FK506-sensitive signals in asthmatic lung inflammation
por: Tomiaki, Chihiro, et al.
Publicado: (2022)

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus
por: Hoy, Michael J., et al.
Publicado: (2022)

Reactivity of redox sensitive paramagnetic nitroxyl contrast agents with reactive oxygen species
por: Nyui, Minako, et al.
Publicado: (2019)

Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers
por: Liu, Youqiang, et al.
Publicado: (2022)

The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats
por: Liu, Jinzhi, et al.
Publicado: (2018)

NAMPT-Mediated Salvage Synthesis of NAD(+) Controls Morphofunctional Changes of Macrophages
por: Venter, Gerda, et al.
Publicado: (2014)

A paclitaxel prodrug nanoparticles with glutathion/reactive oxygen species dual‐responsive and CD206 targeting to improve the anti‐tumour effect
por: Wang, Changhai, et al.
Publicado: (2023)

Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative
por: Delehanty, James B., et al.
Publicado: (2018)

Reactive Oxygen Species Regulate Oxygen-Sensitive Potassium Flux in Rainbow Trout Erythrocytes
por: Bogdanova, Anna Yu, et al.
Publicado: (2001)

From prodrug to pro-prodrug: hypoxia-sensitive antibody–drug conjugates
por: Wang, Yanming, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fh6274rioe9gt2q487sks70scn