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Critical mechanistic features of HIV-1 viral capsid assembly

The maturation of HIV-1 capsid protein (CA) into a cone-shaped lattice capsid is critical for viral infectivity. CA can self-assemble into a range of capsid morphologies made of ~175 to 250 hexamers and 12 pentamers. The cellular polyanion inositol hexakisphosphate (IP6) has recently been demonstrat...

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Detalles Bibliográficos
Autores principales: Gupta, Manish, Pak, Alexander J., Voth, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821859/
https://www.ncbi.nlm.nih.gov/pubmed/36608139
http://dx.doi.org/10.1126/sciadv.add7434