CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation

Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter Ptpn6(spin) mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in Ptpn6(spin) mice bred Ptpn6(spin) × Cd47(−/−) mice that wer...

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Detalles Bibliográficos
Autores principales: Mazgaeen, Lalita, Yorek, Matthew, Saini, Saurabh, Vogel, Peter, Meyerholz, David K., Kanneganti, Thirumala-Devi, Gurung, Prajwal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821860/
https://www.ncbi.nlm.nih.gov/pubmed/36608128
http://dx.doi.org/10.1126/sciadv.ade3942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821860/
https://www.ncbi.nlm.nih.gov/pubmed/36608128
http://dx.doi.org/10.1126/sciadv.ade3942

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