Cargando…

CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation

Mice with SHP1 proteins, which have a single amino acid substitution from tyrosine-208 residue to asparagine (hereafter Ptpn6(spin) mice), develop an autoinflammatory disease with inflamed footpads. Genetic crosses to study CD47 function in Ptpn6(spin) mice bred Ptpn6(spin) × Cd47(−/−) mice that wer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mazgaeen, Lalita, Yorek, Matthew, Saini, Saurabh, Vogel, Peter, Meyerholz, David K., Kanneganti, Thirumala-Devi, Gurung, Prajwal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821860/ https://www.ncbi.nlm.nih.gov/pubmed/36608128 http://dx.doi.org/10.1126/sciadv.ade3942

Ejemplares similares

Acute IL-4 Governs Pathogenic T Cell Responses during Leishmania major Infection
por: Poudel, Barun, et al.
Publicado: (2020)

Recent Advances in Lipopolysaccharide Recognition Systems
por: Mazgaeen, Lalita, et al.
Publicado: (2020)

Leishmania major degrades murine CXCL1 – An immune evasion strategy
por: Yorek, Matthew S., et al.
Publicado: (2019)

SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses
por: Lukens, John R, et al.
Publicado: (2014)

NLRP12 in autoimmune diseases
por: Gurung, Prajwal, et al.
Publicado: (2015)

PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
por: Goh, Pei Kee, et al.
Publicado: (2022)

Distinct role of IL-1β in instigating disease in Sharpin(cpdm) mice
por: Gurung, Prajwal, et al.
Publicado: (2016)

Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice
por: Schwarz, Madeline M., et al.
Publicado: (2023)

Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells
por: Chatterjee, Sushmita, et al.
Publicado: (2023)

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae
por: Smidler, Andrea L., et al.
Publicado: (2023)

Identification of procathepsin L (pCTS-L)–neutralizing monoclonal antibodies to treat potentially lethal sepsis
por: Zhu, Cassie Shu, et al.
Publicado: (2023)

Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen
por: Chen, Grischa Y., et al.
Publicado: (2023)

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
por: Li, Peng, et al.
Publicado: (2023)

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T cell-mediated colitis
por: Li, Bofeng, et al.
Publicado: (2015)

NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice
por: Zhang, Peipei, et al.
Publicado: (2021)

A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infection
por: Iwata-Yoshikawa, Naoko, et al.
Publicado: (2022)

A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium
por: Kon, Edo, et al.
Publicado: (2023)

Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination
por: Welch, Stephen R., et al.
Publicado: (2023)

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities
por: Chen, Yaozong, et al.
Publicado: (2022)

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
por: Van Opdenbosch, Nina, et al.
Publicado: (2014)

PI(4,5)P(2)-dependent regulation of endothelial tip cell specification contributes to angiogenesis
por: Davies, Elizabeth M., et al.
Publicado: (2023)

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
por: Gurung, Prajwal, et al.
Publicado: (2015)

ATP-responsive biomolecular condensates tune bacterial kinase signaling
por: Saurabh, Saumya, et al.
Publicado: (2022)

Plasma iron controls neutrophil production and function
por: Frost, Joe N., et al.
Publicado: (2022)

Shigella induces epigenetic reprogramming of zebrafish neutrophils
por: Gomes, Margarida C., et al.
Publicado: (2023)

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens
por: Monteith, Andrew J., et al.
Publicado: (2021)

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy
por: Zhang, Jiahui, et al.
Publicado: (2022)

How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth
por: Benn, Mario C., et al.
Publicado: (2023)

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease
por: Malireddi, R.K. Subbarao, et al.
Publicado: (2019)

Neutrophil-intrinsic TNF receptor signaling orchestrates host defense against Staphylococcus aureus
por: Youn, Christine, et al.
Publicado: (2023)

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice
por: Liu, Chao, et al.
Publicado: (2023)

Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced mitochondrial bactericidal activity
por: Darroch, Hannah, et al.
Publicado: (2023)

Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow
por: Bonadonna, Michael, et al.
Publicado: (2022)

Synthetic neutrophil extracellular traps dissect bactericidal contribution of NETs under regulation of α-1-antitrypsin
por: Yang, Ting, et al.
Publicado: (2023)

A secreted sirtuin from Campylobacter jejuni contributes to neutrophil activation and intestinal inflammation during infection
por: Callahan, Sean M., et al.
Publicado: (2023)

The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
por: Carrillo-Garcia, Julia, et al.
Publicado: (2021)

Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
por: Lickert, Sebastian, et al.
Publicado: (2022)

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
por: Malireddi, R.K. Subbarao, et al.
Publicado: (2018)

Critical role of caspase-8–mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis
por: Qi, Xiaopeng, et al.
Publicado: (2016)

The recent evolutionary rescue of a staple crop depended on over half a century of global germplasm exchange
por: Muleta, Kebede T., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0u4ujgtff4uv5cin55ak202drn