Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep

Genome-wide association studies (GWAS) in humans have identified loci robustly associated with several heritable diseases or traits, yet little is known about the functional roles of the underlying causal variants in regulating sleep duration or quality. We applied an ATAC-seq/promoter focused Captu...

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Detalles Bibliográficos
Autores principales: Palermo, Justin, Chesi, Alessandra, Zimmerman, Amber, Sonti, Shilpa, Pahl, Matthew C., Lasconi, Chiara, Brown, Elizabeth B., Pippin, James A., Wells, Andrew D., Doldur-Balli, Fusun, Mazzotti, Diego R., Pack, Allan I., Gehrman, Phillip R., Grant, Struan F.A., Keene, Alex C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821868/
https://www.ncbi.nlm.nih.gov/pubmed/36608130
http://dx.doi.org/10.1126/sciadv.abq0844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821868/
https://www.ncbi.nlm.nih.gov/pubmed/36608130
http://dx.doi.org/10.1126/sciadv.abq0844

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