Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation

Deposition of tau protein aggregates in the brain of affected individuals is a defining feature of “tauopathies,” including Alzheimer’s disease. Studies of human brain tissue and various model systems of tauopathy report that toxic forms of tau negatively affect nuclear and genomic architecture, ide...

Descripción completa

Detalles Bibliográficos
Autores principales: Ochoa, Elizabeth, Ramirez, Paulino, Gonzalez, Elias, De Mange, Jasmine, Ray, William J., Bieniek, Kevin F., Frost, Bess
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821943/
https://www.ncbi.nlm.nih.gov/pubmed/36608133
http://dx.doi.org/10.1126/sciadv.abq5423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821943/
https://www.ncbi.nlm.nih.gov/pubmed/36608133
http://dx.doi.org/10.1126/sciadv.abq5423

Ejemplares similares