Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Novel multitarget-directed ligands BIGI 4a-d and BIGI 5a-d were designed and synthesized with a simple and cost-efficient procedure via a one-pot three-component Biginelli reaction targeting acetyl-/butyrylcholinesterases inhibition, calcium channel antagonism, and antioxidant ability. Among these m...

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Detalles Bibliográficos
Autores principales: Malek, Rim, Simakov, Alexey, Davis, Audrey, Maj, Maciej, Bernard, Paul J., Wnorowski, Artur, Martin, Helene, Marco-Contelles, José, Chabchoub, Fakher, Dallemagne, Patrick, Rochais, Christophe, Jozwiak, Krzysztof, Ismaili, Lhassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822022/
https://www.ncbi.nlm.nih.gov/pubmed/36615267
http://dx.doi.org/10.3390/molecules28010071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822022/
https://www.ncbi.nlm.nih.gov/pubmed/36615267
http://dx.doi.org/10.3390/molecules28010071

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