Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors

Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcriptional elongation, through which short-lived antiapoptotic proteins are overexpressed and make cancer cells resistant to apoptosis. Therefore, CDK9 inhibition depletes antiapoptotic proteins, which in turn leads to the reinstatement...

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Detalles Bibliográficos
Autores principales: Alkahtani, Hamad M., Zen, Amer Alhaj, Obaidullah, Ahmad J., Alanazi, Mohammed M., Almehizia, Abdulrahman A., Ansari, Siddique Akber, Aleanizy, Fadilah Sfouq, Alqahtani, Fulwah Yahya, Aldossari, Rana M., Algamdi, Raghad Abdullah, Al-Rasheed, Lamees S., Abdel-Hamided, Sami G., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822073/
https://www.ncbi.nlm.nih.gov/pubmed/36615314
http://dx.doi.org/10.3390/molecules28010120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822073/
https://www.ncbi.nlm.nih.gov/pubmed/36615314
http://dx.doi.org/10.3390/molecules28010120

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