Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses—including SARS-CoV, MERS-CoV, and SARS-CoV-2—is the papain-li...

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Detalles Bibliográficos
Autores principales: van Vliet, Vera J. E., Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S., Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K., Mark, Brian L., Kikkert, Marjolein, Sidhu, Sachdev S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822107/
https://www.ncbi.nlm.nih.gov/pubmed/36548304
http://dx.doi.org/10.1371/journal.ppat.1011065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822107/
https://www.ncbi.nlm.nih.gov/pubmed/36548304
http://dx.doi.org/10.1371/journal.ppat.1011065

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