Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca(2+) channels, and direct neurotransmitter release toward postsynaptic receptor domains. Simultaneous RIM + ELKS ablation disr...

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Detalles Bibliográficos
Autores principales: Tan, Chao, de Nola, Giovanni, Qiao, Claire, Imig, Cordelia, Born, Richard T, Brose, Nils, Kaeser, Pascal S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822248/
https://www.ncbi.nlm.nih.gov/pubmed/36398873
http://dx.doi.org/10.7554/eLife.79077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822248/
https://www.ncbi.nlm.nih.gov/pubmed/36398873
http://dx.doi.org/10.7554/eLife.79077

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