Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones

1H-benzimidazol-2-yl hydrazones with varying hydroxy and methoxy phenyl moieties were designed. Their effect on tubulin polymerization was evaluated in vitro on porcine tubulin. The compounds elongated the nucleation phase and slowed down the tubulin polymerization comparably to nocodazole. The poss...

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Detalles Bibliográficos
Autores principales: Argirova, Maria, Guncheva, Maya, Momekov, Georgi, Cherneva, Emiliya, Mihaylova, Rositsa, Rangelov, Miroslav, Todorova, Nadezhda, Denev, Petko, Anichina, Kameliya, Mavrova, Anelia, Yancheva, Denitsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822270/
https://www.ncbi.nlm.nih.gov/pubmed/36615483
http://dx.doi.org/10.3390/molecules28010291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822270/
https://www.ncbi.nlm.nih.gov/pubmed/36615483
http://dx.doi.org/10.3390/molecules28010291

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