Cargando…

Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B

Thirteen compounds were isolated from the Canavalia lineata pods and their inhibitory activities against human monoamine oxidase-A (hMAO-A) and -B (hMAO-B) were evaluated. Among them, compounds 8 (medicarpin) and 13 (homopterocarpin) showed potent inhibitory activity against hMAO-B (IC(50) = 0.45 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Jong Min, Jang, Hyun-Jae, Kang, Myung-Gyun, Mun, Seul-Ki, Park, Daeui, Hong, Su-Jin, Kim, Min Ha, Kim, Soo-Young, Yee, Sung-Tae, Kim, Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822396/ https://www.ncbi.nlm.nih.gov/pubmed/36615451 http://dx.doi.org/10.3390/molecules28010258

Ejemplares similares

Anti-Inflammatory Activity of Cajanin, an Isoflavonoid Derivative Isolated from Canavalia lineata Pods
por: Hong, Su-Jin, et al.
Publicado: (2022)

Isolation and characterization of microsatellite markers for Canavalia cathartica and C. lineata (Fabaceae)(1)
por: Yamashiro, Asuka, et al.
Publicado: (2013)

Potent and Selective Inhibitors of Human Monoamine Oxidase A from an Endogenous Lichen Fungus Diaporthe mahothocarpus
por: Jeong, Geum Seok, et al.
Publicado: (2021)

Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
por: Oh, Jong Min, et al.
Publicado: (2021)

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis
por: Jeong, Geum Seok, et al.
Publicado: (2020)

Antigonococcal Activity of (+)-Medicarpin
por: Williams, Daniel, et al.
Publicado: (2021)

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

Metabolites of Medicarpin and Their Distributions in Rats
por: Wang, Hong-Yan, et al.
Publicado: (2019)

Selective Inhibition of Human Monoamine Oxidase B by 5-hydroxy-2-methyl-chroman-4-one Isolated from an Endogenous Lichen Fungus Daldinia fissa
por: Jeong, Geum-Seok, et al.
Publicado: (2021)

Antifungal activity against anthracnose-causing species of homopterocarpin derivatives
por: Martinez, Janio, et al.
Publicado: (2023)

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
por: Oh, Jong Min, et al.
Publicado: (2020)

The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor
por: Zarmouh, Najla O., et al.
Publicado: (2017)

Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells
por: Kim, Jung-Hwan, et al.
Publicado: (2022)

Medicarpin induces lipolysis via activation of Protein Kinase A in brown adipocytes
por: Imran, Khan Mohammad, et al.
Publicado: (2018)

Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions
por: Mathew, Bijo, et al.
Publicado: (2021)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
por: Mathew, Bijo, et al.
Publicado: (2022)

PROPAGATION OF ANDROGRAPHIS LINEATA NEES BY STEM CUTTINGS
por: Balu, S., et al.
Publicado: (1995)

ANTIPOISONOUS PROPERTY OF CANAVALIA VIROSA
por: Jayavardhanan, K.K., et al.
Publicado: (1988)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

Marine natural products with monoamine oxidase (MAO) inhibitory activity
por: Hong, Ahreum, et al.
Publicado: (2020)

Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides
por: Kim, Ji Ho, et al.
Publicado: (2012)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of 2-Phenoxyacetamide Analogues, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors
por: Shen, Wei, et al.
Publicado: (2014)

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies
por: Dhiman, Priyanka, et al.
Publicado: (2020)

Characterization of complete mitochondrial genome of Jaydia lineata (Perciformes, Apogonidae)
por: Liu, Bingjian, et al.
Publicado: (2018)

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2022)

Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase-A and -B Inhibitor
por: Zarmouh, Najla O., et al.
Publicado: (2016)

Monoamine Oxidase A Hypomethylation in Obsessive-Compulsive Disorder: Reversibility By Successful Psychotherapy?
por: Schiele, Miriam A, et al.
Publicado: (2020)

Characterization of the complete chloroplast genome of Canavalia gladiata
por: Zhao, Jun
Publicado: (2021)

Medicago truncatula ABCG10 is a transporter of 4-coumarate and liquiritigenin in the medicarpin biosynthetic pathway
por: Biała, Wanda, et al.
Publicado: (2017)

Medicarpin confers powdery mildew resistance in Medicago truncatula and activates the salicylic acid signalling pathway
por: Gupta, Arunima, et al.
Publicado: (2022)

Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
por: Jayan, Jayalakshmi, et al.
Publicado: (2023)

Smoking Related Diseases: The Central Role of Monoamine Oxidase
por: Rendu, Francine, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_g3p7siqhc70jchot7f25psacjf