Synthesis and Crystal Structure of Adamantylated 4,5,6,7-Tetrahalogeno-1H-benzimidazoles Novel Multi-Target Ligands (Potential CK2, M2 and SARS-CoV-2 Inhibitors); X-ray/DFT/QTAIM/Hirshfeld Surfaces/Molecular Docking Study

A series of new congeners, 1-[2-(1-adamantyl)ethyl]-1H-benzimidazole (AB) and 1-[2-(1-adamantyl)ethyl]-4,5,6,7-tetrahalogeno-1H-benzimidazole (Hal=Cl, Br, I; tClAB, tBrAB, tIAB), have been synthesized and studied. These novel multi-target ligands combine a benzimidazole ring known to show antitumor...

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Detalles Bibliográficos
Autores principales: Latosińska, Jolanta Natalia, Latosińska, Magdalena, Orzeszko, Andrzej, Maurin, Jan Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822452/
https://www.ncbi.nlm.nih.gov/pubmed/36615341
http://dx.doi.org/10.3390/molecules28010147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822452/
https://www.ncbi.nlm.nih.gov/pubmed/36615341
http://dx.doi.org/10.3390/molecules28010147

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