Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates. The living skin equivalent (LSE) is an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with hi...

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Detalles Bibliográficos
Autores principales: Muto, Jun, Fukuda, Shinji, Watanabe, Kenji, Dai, Xiuju, Tsuda, Teruko, Kiyoi, Takeshi, Kameda, Kenji, Kawakami, Ryosuke, Mori, Hideki, Shiraishi, Ken, Murakami, Masamoto, Imamura, Takeshi, Higashiyama, Shigeki, Fujisawa, Yasuhiro, Mizukami, Yoichi, Sayama, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822918/
https://www.ncbi.nlm.nih.gov/pubmed/36609486
http://dx.doi.org/10.1038/s42003-022-04408-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822918/
https://www.ncbi.nlm.nih.gov/pubmed/36609486
http://dx.doi.org/10.1038/s42003-022-04408-3

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