A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer

Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential for the activation of key oncogenes in various cancers. However, the mechanism of action for most tumor-specific...

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Detalles Bibliográficos
Autores principales: Chen, Yongheng, Ying, Ying, Wang, Maolin, Ma, Canjie, Jia, Min, Shi, Liang, Wang, Shilan, Zheng, Xiangyi, Chen, Wei, Shu, Xing-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822945/
https://www.ncbi.nlm.nih.gov/pubmed/36609474
http://dx.doi.org/10.1038/s41419-022-05513-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822945/
https://www.ncbi.nlm.nih.gov/pubmed/36609474
http://dx.doi.org/10.1038/s41419-022-05513-1

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