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A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer

Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential for the activation of key oncogenes in various cancers. However, the mechanism of action for most tumor-specific...

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Detalles Bibliográficos
Autores principales:	Chen, Yongheng, Ying, Ying, Wang, Maolin, Ma, Canjie, Jia, Min, Shi, Liang, Wang, Shilan, Zheng, Xiangyi, Chen, Wei, Shu, Xing-sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822945/ https://www.ncbi.nlm.nih.gov/pubmed/36609474 http://dx.doi.org/10.1038/s41419-022-05513-1

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