Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters

The K(+) channel selectivity filter (SF) is defined by TxGYG amino acid sequences that generate four identical K(+) binding sites (S1-S4). Only two sites (S3, S4) are present in the non-selective bacterial NaK channel, but a four-site K(+)-selective SF is obtained by mutating the wild-type TVGDGN SF...

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Detalles Bibliográficos
Autores principales: Matamoros, Marcos, Ng, Xue Wen, Brettmann, Joshua B., Piston, David W., Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822992/
https://www.ncbi.nlm.nih.gov/pubmed/36609575
http://dx.doi.org/10.1038/s41467-022-35756-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822992/
https://www.ncbi.nlm.nih.gov/pubmed/36609575
http://dx.doi.org/10.1038/s41467-022-35756-7

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