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Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
The K(+) channel selectivity filter (SF) is defined by TxGYG amino acid sequences that generate four identical K(+) binding sites (S1-S4). Only two sites (S3, S4) are present in the non-selective bacterial NaK channel, but a four-site K(+)-selective SF is obtained by mutating the wild-type TVGDGN SF...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822992/ https://www.ncbi.nlm.nih.gov/pubmed/36609575 http://dx.doi.org/10.1038/s41467-022-35756-7 |