Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs

Gated entry of lipophilic ligands into the enclosed hydrophobic pocket in stand-alone Sec14 domain proteins often links lipid metabolism to membrane trafficking. Similar domains occur in multidomain mammalian proteins that activate small GTPases and regulate actin dynamics. The neuronal RhoGEF Kalir...

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Detalles Bibliográficos
Autores principales: Li, Yunfeng, Pustovalova, Yulia, Doukov, Tzanko I., Hoch, Jeffrey C., Mains, Richard E., Eipper, Betty A., Hao, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823006/
https://www.ncbi.nlm.nih.gov/pubmed/36609407
http://dx.doi.org/10.1038/s41467-022-35678-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823006/
https://www.ncbi.nlm.nih.gov/pubmed/36609407
http://dx.doi.org/10.1038/s41467-022-35678-4

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