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Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs
Gated entry of lipophilic ligands into the enclosed hydrophobic pocket in stand-alone Sec14 domain proteins often links lipid metabolism to membrane trafficking. Similar domains occur in multidomain mammalian proteins that activate small GTPases and regulate actin dynamics. The neuronal RhoGEF Kalir...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823006/ https://www.ncbi.nlm.nih.gov/pubmed/36609407 http://dx.doi.org/10.1038/s41467-022-35678-4 |