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Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied s...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823011/ https://www.ncbi.nlm.nih.gov/pubmed/36609484 http://dx.doi.org/10.1038/s41398-022-02289-y |
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author | Beaudoin, Francesca L. An, Xinming Basu, Archana Ji, Yinyao Liu, Mochuan Kessler, Ronald C. Doughtery, Robert F. Zeng, Donglin Bollen, Kenneth A. House, Stacey L. Stevens, Jennifer S. Neylan, Thomas C. Clifford, Gari D. Jovanovic, Tanja Linnstaedt, Sarah D. Germine, Laura T. Rauch, Scott L. Haran, John P. Storrow, Alan B. Lewandowski, Christopher Musey, Paul I. Hendry, Phyllis L. Sheikh, Sophia Jones, Christopher W. Punches, Brittany E. Kurz, Michael C. Swor, Robert A. Murty, Vishnu P. McGrath, Meghan E. Hudak, Lauren A. Pascual, Jose L. Datner, Elizabeth M. Chang, Anna M. Pearson, Claire Peak, David A. Merchant, Roland C. Domeier, Robert M. Rathlev, Niels K. Neil, Brian J. O’ Sergot, Paulina Sanchez, Leon D. Bruce, Steven E. Baker, Justin T. Joormann, Jutta Miller, Mark W. Pietrzak, Robert H. Barch, Deanna M. Pizzagalli, Diego A. Sheridan, John F. Smoller, Jordan W. Harte, Steven E. Elliott, James M. Koenen, Karestan C. Ressler, Kerry J. McLean, Samuel A. |
author_facet | Beaudoin, Francesca L. An, Xinming Basu, Archana Ji, Yinyao Liu, Mochuan Kessler, Ronald C. Doughtery, Robert F. Zeng, Donglin Bollen, Kenneth A. House, Stacey L. Stevens, Jennifer S. Neylan, Thomas C. Clifford, Gari D. Jovanovic, Tanja Linnstaedt, Sarah D. Germine, Laura T. Rauch, Scott L. Haran, John P. Storrow, Alan B. Lewandowski, Christopher Musey, Paul I. Hendry, Phyllis L. Sheikh, Sophia Jones, Christopher W. Punches, Brittany E. Kurz, Michael C. Swor, Robert A. Murty, Vishnu P. McGrath, Meghan E. Hudak, Lauren A. Pascual, Jose L. Datner, Elizabeth M. Chang, Anna M. Pearson, Claire Peak, David A. Merchant, Roland C. Domeier, Robert M. Rathlev, Niels K. Neil, Brian J. O’ Sergot, Paulina Sanchez, Leon D. Bruce, Steven E. Baker, Justin T. Joormann, Jutta Miller, Mark W. Pietrzak, Robert H. Barch, Deanna M. Pizzagalli, Diego A. Sheridan, John F. Smoller, Jordan W. Harte, Steven E. Elliott, James M. Koenen, Karestan C. Ressler, Kerry J. McLean, Samuel A. |
author_sort | Beaudoin, Francesca L. |
collection | PubMed |
description | The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes (http://itr.med.unc.edu/aurora/parcoord/). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored. |
format | Online Article Text |
id | pubmed-9823011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98230112023-01-08 Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort Beaudoin, Francesca L. An, Xinming Basu, Archana Ji, Yinyao Liu, Mochuan Kessler, Ronald C. Doughtery, Robert F. Zeng, Donglin Bollen, Kenneth A. House, Stacey L. Stevens, Jennifer S. Neylan, Thomas C. Clifford, Gari D. Jovanovic, Tanja Linnstaedt, Sarah D. Germine, Laura T. Rauch, Scott L. Haran, John P. Storrow, Alan B. Lewandowski, Christopher Musey, Paul I. Hendry, Phyllis L. Sheikh, Sophia Jones, Christopher W. Punches, Brittany E. Kurz, Michael C. Swor, Robert A. Murty, Vishnu P. McGrath, Meghan E. Hudak, Lauren A. Pascual, Jose L. Datner, Elizabeth M. Chang, Anna M. Pearson, Claire Peak, David A. Merchant, Roland C. Domeier, Robert M. Rathlev, Niels K. Neil, Brian J. O’ Sergot, Paulina Sanchez, Leon D. Bruce, Steven E. Baker, Justin T. Joormann, Jutta Miller, Mark W. Pietrzak, Robert H. Barch, Deanna M. Pizzagalli, Diego A. Sheridan, John F. Smoller, Jordan W. Harte, Steven E. Elliott, James M. Koenen, Karestan C. Ressler, Kerry J. McLean, Samuel A. Transl Psychiatry Article The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes (http://itr.med.unc.edu/aurora/parcoord/). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored. Nature Publishing Group UK 2023-01-07 /pmc/articles/PMC9823011/ /pubmed/36609484 http://dx.doi.org/10.1038/s41398-022-02289-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Beaudoin, Francesca L. An, Xinming Basu, Archana Ji, Yinyao Liu, Mochuan Kessler, Ronald C. Doughtery, Robert F. Zeng, Donglin Bollen, Kenneth A. House, Stacey L. Stevens, Jennifer S. Neylan, Thomas C. Clifford, Gari D. Jovanovic, Tanja Linnstaedt, Sarah D. Germine, Laura T. Rauch, Scott L. Haran, John P. Storrow, Alan B. Lewandowski, Christopher Musey, Paul I. Hendry, Phyllis L. Sheikh, Sophia Jones, Christopher W. Punches, Brittany E. Kurz, Michael C. Swor, Robert A. Murty, Vishnu P. McGrath, Meghan E. Hudak, Lauren A. Pascual, Jose L. Datner, Elizabeth M. Chang, Anna M. Pearson, Claire Peak, David A. Merchant, Roland C. Domeier, Robert M. Rathlev, Niels K. Neil, Brian J. O’ Sergot, Paulina Sanchez, Leon D. Bruce, Steven E. Baker, Justin T. Joormann, Jutta Miller, Mark W. Pietrzak, Robert H. Barch, Deanna M. Pizzagalli, Diego A. Sheridan, John F. Smoller, Jordan W. Harte, Steven E. Elliott, James M. Koenen, Karestan C. Ressler, Kerry J. McLean, Samuel A. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title_full | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title_fullStr | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title_full_unstemmed | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title_short | Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
title_sort | use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823011/ https://www.ncbi.nlm.nih.gov/pubmed/36609484 http://dx.doi.org/10.1038/s41398-022-02289-y |
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