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Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort

The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied s...

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Autores principales: Beaudoin, Francesca L., An, Xinming, Basu, Archana, Ji, Yinyao, Liu, Mochuan, Kessler, Ronald C., Doughtery, Robert F., Zeng, Donglin, Bollen, Kenneth A., House, Stacey L., Stevens, Jennifer S., Neylan, Thomas C., Clifford, Gari D., Jovanovic, Tanja, Linnstaedt, Sarah D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Murty, Vishnu P., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Datner, Elizabeth M., Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Neil, Brian J. O’, Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Baker, Justin T., Joormann, Jutta, Miller, Mark W., Pietrzak, Robert H., Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Koenen, Karestan C., Ressler, Kerry J., McLean, Samuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823011/
https://www.ncbi.nlm.nih.gov/pubmed/36609484
http://dx.doi.org/10.1038/s41398-022-02289-y
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author Beaudoin, Francesca L.
An, Xinming
Basu, Archana
Ji, Yinyao
Liu, Mochuan
Kessler, Ronald C.
Doughtery, Robert F.
Zeng, Donglin
Bollen, Kenneth A.
House, Stacey L.
Stevens, Jennifer S.
Neylan, Thomas C.
Clifford, Gari D.
Jovanovic, Tanja
Linnstaedt, Sarah D.
Germine, Laura T.
Rauch, Scott L.
Haran, John P.
Storrow, Alan B.
Lewandowski, Christopher
Musey, Paul I.
Hendry, Phyllis L.
Sheikh, Sophia
Jones, Christopher W.
Punches, Brittany E.
Kurz, Michael C.
Swor, Robert A.
Murty, Vishnu P.
McGrath, Meghan E.
Hudak, Lauren A.
Pascual, Jose L.
Datner, Elizabeth M.
Chang, Anna M.
Pearson, Claire
Peak, David A.
Merchant, Roland C.
Domeier, Robert M.
Rathlev, Niels K.
Neil, Brian J. O’
Sergot, Paulina
Sanchez, Leon D.
Bruce, Steven E.
Baker, Justin T.
Joormann, Jutta
Miller, Mark W.
Pietrzak, Robert H.
Barch, Deanna M.
Pizzagalli, Diego A.
Sheridan, John F.
Smoller, Jordan W.
Harte, Steven E.
Elliott, James M.
Koenen, Karestan C.
Ressler, Kerry J.
McLean, Samuel A.
author_facet Beaudoin, Francesca L.
An, Xinming
Basu, Archana
Ji, Yinyao
Liu, Mochuan
Kessler, Ronald C.
Doughtery, Robert F.
Zeng, Donglin
Bollen, Kenneth A.
House, Stacey L.
Stevens, Jennifer S.
Neylan, Thomas C.
Clifford, Gari D.
Jovanovic, Tanja
Linnstaedt, Sarah D.
Germine, Laura T.
Rauch, Scott L.
Haran, John P.
Storrow, Alan B.
Lewandowski, Christopher
Musey, Paul I.
Hendry, Phyllis L.
Sheikh, Sophia
Jones, Christopher W.
Punches, Brittany E.
Kurz, Michael C.
Swor, Robert A.
Murty, Vishnu P.
McGrath, Meghan E.
Hudak, Lauren A.
Pascual, Jose L.
Datner, Elizabeth M.
Chang, Anna M.
Pearson, Claire
Peak, David A.
Merchant, Roland C.
Domeier, Robert M.
Rathlev, Niels K.
Neil, Brian J. O’
Sergot, Paulina
Sanchez, Leon D.
Bruce, Steven E.
Baker, Justin T.
Joormann, Jutta
Miller, Mark W.
Pietrzak, Robert H.
Barch, Deanna M.
Pizzagalli, Diego A.
Sheridan, John F.
Smoller, Jordan W.
Harte, Steven E.
Elliott, James M.
Koenen, Karestan C.
Ressler, Kerry J.
McLean, Samuel A.
author_sort Beaudoin, Francesca L.
collection PubMed
description The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes (http://itr.med.unc.edu/aurora/parcoord/). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored.
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spelling pubmed-98230112023-01-08 Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort Beaudoin, Francesca L. An, Xinming Basu, Archana Ji, Yinyao Liu, Mochuan Kessler, Ronald C. Doughtery, Robert F. Zeng, Donglin Bollen, Kenneth A. House, Stacey L. Stevens, Jennifer S. Neylan, Thomas C. Clifford, Gari D. Jovanovic, Tanja Linnstaedt, Sarah D. Germine, Laura T. Rauch, Scott L. Haran, John P. Storrow, Alan B. Lewandowski, Christopher Musey, Paul I. Hendry, Phyllis L. Sheikh, Sophia Jones, Christopher W. Punches, Brittany E. Kurz, Michael C. Swor, Robert A. Murty, Vishnu P. McGrath, Meghan E. Hudak, Lauren A. Pascual, Jose L. Datner, Elizabeth M. Chang, Anna M. Pearson, Claire Peak, David A. Merchant, Roland C. Domeier, Robert M. Rathlev, Niels K. Neil, Brian J. O’ Sergot, Paulina Sanchez, Leon D. Bruce, Steven E. Baker, Justin T. Joormann, Jutta Miller, Mark W. Pietrzak, Robert H. Barch, Deanna M. Pizzagalli, Diego A. Sheridan, John F. Smoller, Jordan W. Harte, Steven E. Elliott, James M. Koenen, Karestan C. Ressler, Kerry J. McLean, Samuel A. Transl Psychiatry Article The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along with associations within and between trajectories. APNS across all ten symptom domains were common in the first two months after trauma. Many risk factors and associations with high symptom burden trajectories were shared across domains. Both across and within traditional diagnostic boundaries, APNS trajectory intercepts, and slopes were substantially correlated. Across all domains, symptom severity in the immediate aftermath of trauma (trajectory intercepts) had the greatest influence on the outcome. An interactive data visualization tool was developed to allow readers to explore relationships of interest between individual characteristics, symptom trajectories, and traditional outcomes (http://itr.med.unc.edu/aurora/parcoord/). Individuals presenting to the ED after MVC commonly experience a broad constellation of adverse posttraumatic symptoms. Many risk factors for diverse APNS are shared. Individuals diagnosed with a single traditional outcome should be screened for others. The utility of multidimensional categorizations that characterize individuals across traditional diagnostic domains should be explored. Nature Publishing Group UK 2023-01-07 /pmc/articles/PMC9823011/ /pubmed/36609484 http://dx.doi.org/10.1038/s41398-022-02289-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Beaudoin, Francesca L.
An, Xinming
Basu, Archana
Ji, Yinyao
Liu, Mochuan
Kessler, Ronald C.
Doughtery, Robert F.
Zeng, Donglin
Bollen, Kenneth A.
House, Stacey L.
Stevens, Jennifer S.
Neylan, Thomas C.
Clifford, Gari D.
Jovanovic, Tanja
Linnstaedt, Sarah D.
Germine, Laura T.
Rauch, Scott L.
Haran, John P.
Storrow, Alan B.
Lewandowski, Christopher
Musey, Paul I.
Hendry, Phyllis L.
Sheikh, Sophia
Jones, Christopher W.
Punches, Brittany E.
Kurz, Michael C.
Swor, Robert A.
Murty, Vishnu P.
McGrath, Meghan E.
Hudak, Lauren A.
Pascual, Jose L.
Datner, Elizabeth M.
Chang, Anna M.
Pearson, Claire
Peak, David A.
Merchant, Roland C.
Domeier, Robert M.
Rathlev, Niels K.
Neil, Brian J. O’
Sergot, Paulina
Sanchez, Leon D.
Bruce, Steven E.
Baker, Justin T.
Joormann, Jutta
Miller, Mark W.
Pietrzak, Robert H.
Barch, Deanna M.
Pizzagalli, Diego A.
Sheridan, John F.
Smoller, Jordan W.
Harte, Steven E.
Elliott, James M.
Koenen, Karestan C.
Ressler, Kerry J.
McLean, Samuel A.
Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title_full Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title_fullStr Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title_full_unstemmed Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title_short Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
title_sort use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823011/
https://www.ncbi.nlm.nih.gov/pubmed/36609484
http://dx.doi.org/10.1038/s41398-022-02289-y
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