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Phosphatidylinositol (3,5)-bisphosphate machinery regulates neurite thickness through neuron-specific endosomal protein NSG1/NEEP21
Phosphatidylinositol (3,5)-bisphosphate [PtdIns(3,5)P(2)] is a critical signaling phospholipid involved in endolysosome homeostasis. It is synthesized by a protein complex composed of PIKfyve, Vac14, and Fig4. Defects in PtdIns(3,5)P(2) synthesis underlie a number of human neurological disorders, in...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823133/ https://www.ncbi.nlm.nih.gov/pubmed/36493904 http://dx.doi.org/10.1016/j.jbc.2022.102775 |