RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs

Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates angiogenesis under hypoxic conditions. To investigate the posttranscriptional regulatory mechanism of HIF1α, we performed a cell-based screening to reveal potential cis-elements and the regulatory RNA-binding proteins that...

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Detalles Bibliográficos
Autores principales: Yamamoto, Hiroto, Uchida, Yutaro, Kurimoto, Ryota, Chiba, Tomoki, Matsushima, Takahide, Ito, Yoshiaki, Inotsume, Maiko, Miyata, Kohei, Watanabe, Kenta, Inada, Masaki, Goshima, Naoki, Uchida, Tokujiro, Asahara, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823215/
https://www.ncbi.nlm.nih.gov/pubmed/36509142
http://dx.doi.org/10.1016/j.jbc.2022.102791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823215/
https://www.ncbi.nlm.nih.gov/pubmed/36509142
http://dx.doi.org/10.1016/j.jbc.2022.102791

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