Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction

Shiga toxin 2a (Stx2a) is the virulence factor of enterohemorrhagic Escherichia coli. The catalytic A1 subunit of Stx2a (Stx2A1) interacts with the ribosomal P-stalk for loading onto the ribosome and depurination of the sarcin–ricin loop, which halts protein synthesis. Because of the intrinsic flexi...

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Detalles Bibliográficos
Autores principales: Kulczyk, Arkadiusz W., Sorzano, Carlos Oscar S., Grela, Przemysław, Tchórzewski, Marek, Tumer, Nilgun E., Li, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823235/
https://www.ncbi.nlm.nih.gov/pubmed/36528064
http://dx.doi.org/10.1016/j.jbc.2022.102795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823235/
https://www.ncbi.nlm.nih.gov/pubmed/36528064
http://dx.doi.org/10.1016/j.jbc.2022.102795

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