Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O

The synthesis of α,α-dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI(2) and D(2)O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the...

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Autores principales: Li, Hengzhao, Hou, Yuxia, Peng, Mengqi, Wang, Lijun, Li, Junyu, Ning, Lei, Lai, Zemin, Li, Yixuan, An, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823311/
https://www.ncbi.nlm.nih.gov/pubmed/36615608
http://dx.doi.org/10.3390/molecules28010416
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author Li, Hengzhao
Hou, Yuxia
Peng, Mengqi
Wang, Lijun
Li, Junyu
Ning, Lei
Lai, Zemin
Li, Yixuan
An, Jie
author_facet Li, Hengzhao
Hou, Yuxia
Peng, Mengqi
Wang, Lijun
Li, Junyu
Ning, Lei
Lai, Zemin
Li, Yixuan
An, Jie
author_sort Li, Hengzhao
collection PubMed
description The synthesis of α,α-dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI(2) and D(2)O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the synthesis of valuable deuterated agrochemicals and their building blocks.
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spelling pubmed-98233112023-01-08 Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O Li, Hengzhao Hou, Yuxia Peng, Mengqi Wang, Lijun Li, Junyu Ning, Lei Lai, Zemin Li, Yixuan An, Jie Molecules Article The synthesis of α,α-dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI(2) and D(2)O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the synthesis of valuable deuterated agrochemicals and their building blocks. MDPI 2023-01-03 /pmc/articles/PMC9823311/ /pubmed/36615608 http://dx.doi.org/10.3390/molecules28010416 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Hengzhao
Hou, Yuxia
Peng, Mengqi
Wang, Lijun
Li, Junyu
Ning, Lei
Lai, Zemin
Li, Yixuan
An, Jie
Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title_full Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title_fullStr Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title_full_unstemmed Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title_short Reductive Deuteration of Acyl Chlorides for the Synthesis of α,α-Dideuterio Alcohols Using SmI(2) and D(2)O
title_sort reductive deuteration of acyl chlorides for the synthesis of α,α-dideuterio alcohols using smi(2) and d(2)o
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823311/
https://www.ncbi.nlm.nih.gov/pubmed/36615608
http://dx.doi.org/10.3390/molecules28010416
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