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In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices
Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. The hepat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823597/ https://www.ncbi.nlm.nih.gov/pubmed/36615701 http://dx.doi.org/10.3390/nu15010043 |
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author | Ruiz de Azua, Ma. Josefina Cruz-Carrión, Álvaro Muguerza, Begoña Aragonès, Gerard Arola-Arnal, Anna Romero, María Paz Bravo, Francisca Isabel Suarez, Manuel |
author_facet | Ruiz de Azua, Ma. Josefina Cruz-Carrión, Álvaro Muguerza, Begoña Aragonès, Gerard Arola-Arnal, Anna Romero, María Paz Bravo, Francisca Isabel Suarez, Manuel |
author_sort | Ruiz de Azua, Ma. Josefina |
collection | PubMed |
description | Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. The hepatic gene expression of key enzymes in lipid metabolism was also evaluated. Animals were classified in three photoperiods (L6, L12, and L18) and in three treatments (vehicle: VH; local tomato: LT; and non-local tomato: nLT). We measured serum metabolic parameters and the gene expression of liver enzymes related to lipid metabolism (Acc1, Cpt1a, Had, Fas1, Srebp-1c, Fatp5, Cd36). LT consumption in season decreased cardiovascular risk 1 and coefficient atherogenic by 1.81 (p = 0.031) and in L6 decreased TAG and glucose (p = 0.046; p = 0.024). The L18-LT animals had decreased total cholesterol (p = 0.029) and gene expression of Srebp1-c (p = 0.022) but increased expression of Acc1 (p = 0.032). The treatments significantly affected the expression of Acc1 and Fas1 in the liver and the levels of serum TAG and glucose. A significant effect of photoperiod on serum concentration of glucose, insulin, HOMA index, and on the hepatic expression of Srep1-c, Fas1, and Acc1 was observed. |
format | Online Article Text |
id | pubmed-9823597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98235972023-01-08 In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices Ruiz de Azua, Ma. Josefina Cruz-Carrión, Álvaro Muguerza, Begoña Aragonès, Gerard Arola-Arnal, Anna Romero, María Paz Bravo, Francisca Isabel Suarez, Manuel Nutrients Article Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. The hepatic gene expression of key enzymes in lipid metabolism was also evaluated. Animals were classified in three photoperiods (L6, L12, and L18) and in three treatments (vehicle: VH; local tomato: LT; and non-local tomato: nLT). We measured serum metabolic parameters and the gene expression of liver enzymes related to lipid metabolism (Acc1, Cpt1a, Had, Fas1, Srebp-1c, Fatp5, Cd36). LT consumption in season decreased cardiovascular risk 1 and coefficient atherogenic by 1.81 (p = 0.031) and in L6 decreased TAG and glucose (p = 0.046; p = 0.024). The L18-LT animals had decreased total cholesterol (p = 0.029) and gene expression of Srebp1-c (p = 0.022) but increased expression of Acc1 (p = 0.032). The treatments significantly affected the expression of Acc1 and Fas1 in the liver and the levels of serum TAG and glucose. A significant effect of photoperiod on serum concentration of glucose, insulin, HOMA index, and on the hepatic expression of Srep1-c, Fas1, and Acc1 was observed. MDPI 2022-12-22 /pmc/articles/PMC9823597/ /pubmed/36615701 http://dx.doi.org/10.3390/nu15010043 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruiz de Azua, Ma. Josefina Cruz-Carrión, Álvaro Muguerza, Begoña Aragonès, Gerard Arola-Arnal, Anna Romero, María Paz Bravo, Francisca Isabel Suarez, Manuel In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title | In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title_full | In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title_fullStr | In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title_full_unstemmed | In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title_short | In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices |
title_sort | in-season consumption of locally produced tomatoes decreases cardiovascular risk indices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823597/ https://www.ncbi.nlm.nih.gov/pubmed/36615701 http://dx.doi.org/10.3390/nu15010043 |
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