Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site

Background: As a result of the paucity of treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. New molecules are needed, and drug discovery research is oriented toward targeting proteins crucial for parasite survival. Among them, trypanothione reductase (TR) is of...

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Detalles Bibliográficos
Autores principales: Madia, Valentina Noemi, Ialongo, Davide, Patacchini, Elisa, Exertier, Cécile, Antonelli, Lorenzo, Colotti, Gianni, Messore, Antonella, Tudino, Valeria, Saccoliti, Francesco, Scipione, Luigi, Ilari, Andrea, Costi, Roberta, Di Santo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823735/
https://www.ncbi.nlm.nih.gov/pubmed/36615531
http://dx.doi.org/10.3390/molecules28010338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823735/
https://www.ncbi.nlm.nih.gov/pubmed/36615531
http://dx.doi.org/10.3390/molecules28010338

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