New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells

Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation of their activities within the NF-κB pathway correlates with chemoresistance events, even after treatment with IAPs-antagonists in the clinic (Smac-mimetics). The molecule FC2 was identified as a NF...

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Detalles Bibliográficos
Autores principales: Fiore, Michele, Mosconi, Michele, Bonì, Francesco, Parodi, Alice, Salis, Annalisa, Tasso, Bruno, Mastrangelo, Eloise, Millo, Enrico, Cossu, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823934/
https://www.ncbi.nlm.nih.gov/pubmed/36615638
http://dx.doi.org/10.3390/molecules28010446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823934/
https://www.ncbi.nlm.nih.gov/pubmed/36615638
http://dx.doi.org/10.3390/molecules28010446

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