A Novel Multi-Target Mu/Delta Opioid Receptor Agonist, HAGD, Produced Potent Peripheral Antinociception with Limited Side Effects in Mice and Minimal Impact on Human Sperm Motility In Vitro

Pain is a common clinical symptom among patients. Although various opioid analgesics have been developed, their side effects hinder their application. This study aimed to develop a novel opioid analgesic, HAGD (H-Tyr-D-AIa-GIy-Phe-NH(2)), with limited side effects. In vivo studies on mouse models as...

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Detalles Bibliográficos
Autores principales: Li, Fangfang, Yue, Feng, Zhang, Wei, Xu, Biao, Wang, Yiqing, Zhang, Xuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824695/
https://www.ncbi.nlm.nih.gov/pubmed/36615612
http://dx.doi.org/10.3390/molecules28010427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824695/
https://www.ncbi.nlm.nih.gov/pubmed/36615612
http://dx.doi.org/10.3390/molecules28010427

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